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Microinflammation in the intestinal mucosa and symptoms of irritable bowel syndrome, 2021, Yoshimoto et al

Discussion in 'Other health news and research' started by Andy, Dec 3, 2021.

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  1. Andy

    Andy Committee Member

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    21,809
    Location:
    Hampshire, UK
    Abstract

    Background
    Potential etiological mechanisms of irritable bowel syndrome (IBS) have been reported, and emerging data suggest that immune activation is present in a major subset of IBS, especially in those with diarrhea. Intestinal mucosal mast cell and intraepithelial lymphocyte (IEL) infiltration and related factors were examined in patients with IBS. In addition, the correlations of symptoms and micro-inflammation were assessed.

    Methods
    Intestinal biopsy specimens were obtained from patients with IBS and controls. Mast cells and IELs were stained with specific antibodies. The mRNA levels of cytokines and chemokines were assessed by quantitative reverse transcription polymerase chain reaction.

    Results
    Infiltration of mast cells in the duodenum was significantly higher in IBS patients than in control subjects. The infiltration of IELs was higher in the duodenum and terminal ileum of IBS patients compared to the control subjects. The numbers of duodenal and ileal IELs were significantly correlated. The number of IELs but not mast cells in the duodenum and terminal ileum was significantly correlated with diarrhea frequency in control subjects and IBS patients. The expression level of the chemotactic chemokine CXCL11 was significantly higher in the duodenum of IBS patients.

    Conclusion
    Duodenal mast cells and IELs were increased in IBS patients. In addition, a positive correlation was found between the number of duodenal and ileal IELs and the frequency of diarrhea. Given that the present study was strictly observational, further studies are needed to clarify the pathophysiological functions associated with micro-inflammation in IBS.

    Paywall, https://link.springer.com/article/10.1007/s00535-021-01838-4
     
    MEMarge, oldtimer, Simbindi and 10 others like this.
  2. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    9,574
    Location:
    UK

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