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Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue: Fluge et al Jan 2020

Discussion in 'Other Health News and Research' started by Sly Saint, Jan 11, 2020.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

  2. Rain

    Rain Senior Member (Voting Rights)

    I know dr Phair has some theories on Trypyophan being a contributor to the IDO metabolic trap. But what are they referring to here?
  3. Hutan

    Hutan Moderator Staff Member

    New Zealand
    From the Discussion:
    The authors are suggesting fatigue after cancer treatment is different to CFS/ME:
    Re the Trp levels:
    So lymphoma survivors with fatigue and people with CFS/ME had similar levels of Trp (averages 73.4 and 73.4). And lymphoma survivors without fatigue and healthy controls from the CFS/ME study both had higher levels (77.6 and 77.8).

    But here's the graph of Trp levels from this study of cancer survivors (Trp is the graph on the left):
    Screen Shot 2020-01-12 at 5.27.28 PM.png

    Look at the huge amount of overlap (and note the truncated scale). If there's really a difference in average Trp levels between cancer survivors with and without fatigue, it's certainly not a consistent difference at the patient level.

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