Medscape article: Low-Dose Naltrexone: An Inexpensive Medicine for Many Ills?

Article by Miriam Tucker - Low-Dose Naltrexone: An Inexpensive Medicine for Many Ills?

https://www.medscape.com/viewarticle/926611

(to read article I think you must register with Medscape)

 

This is good news. Or is it?

We hear a lot of LDN and ME/CFS through articles and case reports. How promising the meds is, and about it's benefits.
But we need a big clinical trial on LDN! To proof it. If not, these articles gives no new info. As any other articles about probable meds who can be good for ME/CFS patients. For example, no way my doctor will subscribe LDN to me as things are now, no matter what these articles conveys. I wouldn't try it either, because the facts are largely missing.

That said, I have heard a couple other patients have tried it, with success. Maybe this is something! I do not have access to Medscape, so I couldn't read the whole thing. And maybe I have missed something (I'm not an expert on LDN-studies). But do you know if there will be clinical trials on LDN and ME/CFS? I really hope so!

 

https://www.s4me.info/threads/low-d...me-bolton-chapman-van-marwijk-jan-2020.13137/
https://www.s4me.info/threads/low-d...atigue-syndrome-me-cfs-2019-polo-et-al.12426/
https://www.s4me.info/threads/naltr...rom-me-cfs-patients-cabanas-et-al-2019.11797/

 

don't know if this is any good or not

Valarie from the United States shares her Chronic Fatigue Syndrome (CFS/ME) & Low Dose Naltrexone (LDN) Story

https://ldnresearchtrust.org/valari...-syndrome-cfsme-low-dose-naltrexone-ldn-story

 

When I asked for some to try, my doctor was fine with prescribing it, because it's at such a low dosage that the chance of bad side effects was negligible. It worked extremely well for me, blocking my neuropathic pains, but didn't affect any other ME symptoms. After a year or two on LDN, I no longer needed it because the neuropathic pains had stopped. The minimum effective dose I worked out for me was 2.5 mg sublingually (needed ~1/3 less that way) alternated mornings and evenings every second day. At such a low dosage, any unnoticed side-effects from it would have been dwarfed by the health benefits of the exercise I was able to do without the pain. LDN sure improved my quality of life.

 

I tried NDL for several months. For many years I've had a foreearm itch that was not relieved by any medication. LDN seeemed to fix that. One the other hand, it seemed to leave me with a numbness. Eventually I just stopped taking it. For me, it is one of many medications that provides a temporary enhancement of functionality but only serves to wear one down in the longer term.

 

I tried LDN back in 2015 and it didn't do anything for me.