Malmö POTS symptom score: Assessing symptom burden in postural orthostatic tachycardia syndrome, 2021, Fedorowski et al

Published Sept 16, 2022

Jasmina Medic Spahic, Victor Hamrefors, Madeleine Johansson, Fabrizio Rici, Olle Melander, Richard Sutton, Artur Fedorowski

Abstract
Background
Postural orthostatic tachycardia syndrome (POTS) is a common cardiovascular autonomic disorder characterized by excessive heart rate (HR) increase on standing and symptoms of orthostatic intolerance, posing significant limitations on functional capacity. No objective tool exists to classify symptom burden in POTS.

Methods
We conducted a case–control study in 62 POTS patients and 50 healthy controls to compare symptom burden between groups using the newly developed, self-rating, 12-item, Malmö POTS Score (MAPS; 0–10 per item, total range 0–120) based on patients own perception of symptoms through visual analogue scale assessment. We have also explored correlations between symptom severity assessed by MAPS, basic clinical parameters and postural haemodynamic changes.

Results
POTS patients showed significantly higher total MAPS score (78 ± 20 vs. 14 ± 12, p < 0.001), higher baseline systolic blood pressure (BP), diastolic BP and HR (p < 0.001) compared with healthy controls. The most prominent symptoms in POTS were palpitations, fatigue and concentration difficulties. Haemodynamic parameters on standing were significantly correlated with palpitations in POTS after adjustment for age and sex (lower systolic and diastolic BP, and higher HR) (p < 0.001 for all). Orthostatic HR was significantly associated with concentration difficulties and total MAPS score. The optimal cut-point value of MAPS to differentiate POTS and healthy controls was ≥42 (sensitivity, 97%; specificity, 98%).

Conclusions
Symptom severity, as assessed by MAPS score, is fivefold higher in POTS compared with healthy individuals. The new MAPS score can be useful as a semiquantitative system to assess symptom burden, monitor disease progression and evaluate pre-test likelihood of disease.

https://onlinelibrary.wiley.com/doi/10.1111/joim.13566

 

This seems much better than average. Asking about the relevant symptoms, what a novel concept. I hope to see more of that, using prior information and knowledge in a smart way.

Although I think this would be more of a dysautonomia score, as it doesn't look at heart rate. So a smart classification would be making this a dysautonomia score, with additional significant tachycardia for POTS.