Impaired immune surveillance accelerates accumulation of senescent cells and aging (2018) - Prof. Valery Krizhanovsky and Dr. Yossi Ovadya

Sly Saint · Jan 2, 2019

Not sure if this is of any relevance.

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Yossi Ovadya,

Tomer Landsberger,

Hanna Leins,

Ezra Vadai,

Hilah Gal,

Anat Biran,

Reut Yosef,

Adi Sagiv,

Amit Agrawal,

Alon Shapira,

Joseph Windheim,

Michael Tsoory,

Reinhold Schirmbeck,

Ido Amit,

Hartmut Geiger &

Valery Krizhanovsky

Abstract

Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, preventing their propagation in tissues. However, senescent cells accumulate in tissues in advanced age, where they might promote tissue degeneration and malignant transformation.

The extent of immune-system involvement in regulating age-related accumulation of senescent cells, and its consequences, are unknown. Here we show that Prf1−/− mice with impaired cell cytotoxicity exhibit both higher senescent-cell tissue burden and chronic inflammation.
They suffer from multiple age-related disorders and lower survival. Strikingly, pharmacological elimination of senescent-cells by ABT-737 partially alleviates accelerated aging phenotype in these mice. In LMNA+/G609G progeroid mice, impaired cell cytotoxicity further promotes senescent-cell accumulation and shortens lifespan. ABT-737 administration during the second half of life of these progeroid mice abrogates senescence signature and increases median survival.

Our findings shed new light on mechanisms governing senescent-cell presence in aging, and could motivate new strategies for regenerative medicine.
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https://www.nature.com/articles/s41467-018-07825-3

article about the article:

If only we could keep our bodies young, healthy and energetic, even as we attain the wisdom of our years. New research at the Weizmann Institute of Science suggests this dream could be at least partly obtainable in the future. The results of this research, led by Prof. Valery Krizhanovsky and Dr. Yossi Ovadya in the Molecular Cell Biology Department, were recently published in Nature Communications.

The research began with an investigation into the way that the immune system is involved in a crucial activity: clearing away old, senescent cells that spell trouble for the body when they hang around. Senescent cells - not completely dead but suffering loss of function or irreparable damage - have been implicated in diseases of aging by promoting inflammation.
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full article (media) here:
https://www.dailytimes.live/tunis/study-helping-immune-system-clear-cells-aging-mice-helped-00880480

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Impaired immune surveillance accelerates accumulation of senescent cells and aging (2018) - Prof. Valery Krizhanovsky and Dr. Yossi Ovadya

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Impaired immune surveillance accelerates accumulation of senescent cells and aging (2018) - Prof. Valery Krizhanovsky and Dr. Yossi Ovadya

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