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Immunoglobulin for chronic fatigue syndrome (CFS/ME): systematic reference list

Discussion in 'BioMedical ME/CFS News' started by John Mac, Oct 10, 2018 at 4:05 PM.

  1. John Mac

    John Mac Established Member (Voting Rights)

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    Downloadable pdf file is in Norwegian

    https://www.fhi.no/en/publ/2018/Immunoglobulin-for-chronic-fatigue-syndrome-CFS-ME/
     
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  2. Alvin

    Alvin Senior Member (Voting Rights)

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    Did it successfully treat symptoms?
     
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  3. John Mac

    John Mac Established Member (Voting Rights)

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    The English summary suggests they didn't try to, but maybe our Norwegian members could read the pdf for us
     
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  4. Trish

    Trish Moderator Staff Member

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    It looks like it is simply a literature search, and the end result is a list of 7 trials between 1986 and 1999, and 8 systematic reviews.

    It seems a bit excessive for 8 reviews to have been done of 7 trials. What am I missing here?
     
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  5. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    None of the reviews are actually of IVIG in ME. They are general reviews of ME treatment or of use of IVIG. Hardly surprising that there are eight in all I guess.
     
  6. Amw66

    Amw66 Senior Member (Voting Rights)

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    Nigel Speight used this with some success in paediatric cases . I' m sure I saw this in an interview clip.
     
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  7. Amw66

    Amw66 Senior Member (Voting Rights)

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  8. Denise

    Denise Senior Member (Voting Rights)

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  9. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

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    UK guidelines previously recommended that IVIG not be given for CFS and instead CBT be used.

    See 2nd message below


    https://www.bmj.com/rapid-response/...t-decided-immunoglobulin-was-not-suitable-cfs



    ---
    https://www.bmj.com/content/337/bmj.a1831/rapid-responses

     
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  10. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    This is one of the 7 papers. In fact two of the papers refer to this study.
     
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  11. inox

    inox Established Member (Voting Rights)

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    It's only a list of possible relevant papers - studies and systematic reviews. The result of a systematic litterature search, nothing more. And that doesn't include actually reading the papers either, selection is based on title and abstract only:

    (google translate: )
    Not really sure how usefull such litrature seaches are, but they are a thing.

    Edit:

    Larun has given expert input on this, as senior researcher.
    Kjetil Brurberg has signed the foreword, as head of the department.
     
    Last edited: Oct 11, 2018 at 9:49 AM
  12. Alvin

    Alvin Senior Member (Voting Rights)

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    Dear god, withhold treatment and tell people their illness doesn't exist while they keep deteriorating
    Who is protecting these people from a medical ethics hearing?
     
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  13. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    So how strong is the evidence for IVIg? Is this another weak area?
     
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