I was prescribed this medication in May and it was very effective for my eczema. I had it for more than 10 years and it was away in two weeks with the use of this cream. However, I was told not to use long term as it can cause cancer. I had two flares and used only for a day or two and that again cleared it. I'm absolutely over the moon with this. It made a huge improvement in my life. Has anybody else use this? Apparently, the ingredient is an immune suppressive, calcineurin inhibitor. It is discovered for organ transplantation. This makes me think again my immune system attacks my own body. I also have Hashimoto's and I have never suffered any form of allergy before I had ME.