Hi Everyone My recent muscle biopsy of my thigh has led to what seems like very relevant research findings that should be followed up urgently by researchers looking at muscle biopsies. I am bed bound and had been for 5 months before the biopsy. One of my results was: Severe Type II Muscle Atrophy First I looked for other research and found this 1991 study: Mitochondrial abnormalities in the postviral fatigue syndrome* W. M. H. Behan1, I. A. R. More1, and P. O. Behan In it they found that 39 of 50 patients that they classified as CFS has Type II muscle atrophy But here's the thing... In the most recent 2 papers that I could find that differentiated between the type of circumstances that result in specifically Type 1 or Type 2 muscle fibre atrophy... Muscle type and fiber type specificity in muscle wasting☆ Author links open overlay panelStefanoCiciliota1Alberto C.Rossia12Kenneth A.DyaraBertBlaauwabStefanoSchiaffinoac Muscle type and fiber type specificity in muscle wasting. Ciciliot S1, Rossi AC, Dyar KA, Blaauw B, Schiaffino S. They explain that disuse/inactivity results in such more Type 1 atrophy than Type II atrophy so one would expect to see a lot more Type 1 atrophy in Muscle Biopsies of ME patients. Yet on the limited evidence so far and certainly in my case where I hadn't used legs for 5 months that doesn't seem to be the case. Interestingly, the 2nd paper generalises the group of conditions that cause Type II atrophy as Malnutrition and Inflammation which fits the Metabolic/Immune ME theories pretty well. I am not a biomedical mind but they mention different pathways which may contribute to Type II atrophy including TGFb (for those of you who are scientific minds you might be interested in reading these papers as at least in my view they counter the deconditioning arguments nicely if research groups doing muscle biopsies find that we have Type II atrophy and might point towards factors that are contributing to this.