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Discovery Forum 2017: Dr. Nancy Klimas

Discussion in 'BioMedical ME/CFS News' started by Diwi9, Aug 18, 2018.

  1. Diwi9

    Diwi9 Senior Member (Voting Rights)

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    I don't think this one has been posted. Dr. Klimas discusses her advances with Gulf War Illness and how she was able to use ME/CFS as a comparison model. She shows some great slides and discusses the direction she would like to proceed in for possible future clinical trials.

     
    Alvin, Sly Saint, Wonko and 7 others like this.
  2. Inara

    Inara Senior Member (Voting Rights)

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    She has two summary slides at the end. These are quite interesting. (The rest is, too :) )

    They are planning a phase 1 trial on ME, but still need the funding. They want to apply to NIH for the phase 2 funding after that.

    They are transporting knowledge about GWI (from in silico an animal models) to ME.
     
    adambeyoncelowe, Mij, Forbin and 3 others like this.
  3. Pechius

    Pechius Senior Member (Voting Rights)

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    You watch this presentation and then think about all the nonsense that UK psychiatrists are hypothesizing about ME/CFS... Oh my.

    Why is psychiatry stuck in the 19th century?
     
    Wonko, diwa, adambeyoncelowe and 2 others like this.
  4. Forbin

    Forbin Senior Member (Voting Rights)

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    Interesting concept of the "trigger." You could see this happening with some kind of infection coincident with a period of high stress (which pretty much describes my onset).

    Also, perhaps getting a bad infection during a time of stress makes it more likely that it will proceed to some kind of mild neuro-inflammation; so the two things may come together more often than merely by chance.

    Decades ago, about a month after onset, my neurologist suspected I'd gone through a mild encephalitis (based on my spinal tap).

    I've sometimes suspected that the dubious link between ME/CFS and "type A personality / high achievers" might be that such people may tend to jump back into high stress activity too quickly following some kind of viral infection.
     
    Last edited: Aug 21, 2018
    Wonko, Inara and Pechius like this.
  5. Inara

    Inara Senior Member (Voting Rights)

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    I wouldn't underestimate pressure from the job. Many people lose their job if they allow themselves to be on sick leave. Lesser reasons are enough to drive people to work although sick - e.g. what might the boss or the colleagues think, I have so much work to do, there's a deadline.

    It's not always about choices. Real life today is (and maybe always was?) pure stress, this is the normal setting for most people.
     
  6. Forbin

    Forbin Senior Member (Voting Rights)

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    Well, for me, what you say did figure into my returning to work too quickly. I was trying to break into an industry via a job where I could easily be replaced and where being there every day was critical (it also didn't pay sick time, but that was not really the issue for me).

    It wasn't a matter of being a workaholic. It was more that I felt young and indestructible and I assumed that I didn't need to be 100% to go back to work. I'd gotten away with it before - - but I'd never been so run down prior to getting the flu before.
     
  7. Inara

    Inara Senior Member (Voting Rights)

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    Exactly. Same here. But in fact, what came on top of my view "no problem to behave normal with an infection", I felt it was expected from me to behave like that. I was new in the company. It went like "It's your choice" - a long glance.

    This type A stuff is crap in my opinion.
    I'm definitely not type A by the way. But, which is quite normal in humanity, there are several "bondages" which force you to become a bit like "Type A", no matter if you like it or not.
     
  8. Mij

    Mij Senior Member (Voting Rights)

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    I caught the viral infection during a career transition, it was somewhat stressful but the viral infection prevented me from working for 8 months, so I stayed home and took very good care of myself. I was able to return to work after 8 months, I felt refreshed and 95% improved. I felt recovered until the 3 week mark when my sleep became disrupted (feeling wired up) and started walking like a drunk on my 15 minute walk to work. I went downhill very quickly after that and became disabled. It wasn't during a stressful period.
     
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  9. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    do you think the so called 'experts' in the UK ever watch/read any of this(?) stupid question; I doubt they would understand it anyway:D

    One of the last slides:

    Nancy Klimas presentation.jpg
    I'm not sure why the reference to CBT is there though?
     
    Inara, Wonko and adambeyoncelowe like this.

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