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Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration, 2019, O'Hara et al

Discussion in 'Other health news and research' started by Andy, Oct 18, 2019.

  1. Andy

    Andy Committee Member

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    21,814
    Location:
    Hampshire, UK
    Open access, https://www.frontiersin.org/articles/10.3389/fnmol.2019.00219/full
     
  2. sb4

    sb4 Senior Member (Voting Rights)

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    144
    Interesting. It appears some people had success with DCA over on PR but it did nothing for me.
     
    Andy likes this.
  3. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    @mariovitali DRP1 mentioned again in this paper. A quick search shows there seems to be quite a few papers showing change of DRP1 with Dichloroacetate
     
    mariovitali and Andy like this.
  4. mariovitali

    mariovitali Senior Member (Voting Rights)

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    499
    I added dichloroacetate and several other related topics to mito fission/fusion/drp1 etc to see what we are getting.
     
    Last edited: Oct 19, 2019
    Andy and wigglethemouse like this.
  5. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

    Messages:
    954
    There are some patient stories on PR. It seems quite a few felt they developed neuropathy or thought their neuropathy got worse, despite taking B1 and ALA. So there is some significant risk.
    https://forums.phoenixrising.me/thr...ichloroacetate-pilot-trial.58184/post-2222970

    This papers states how DCA affects mitochondria (in mice)
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359228/
    Other articles talk about DCA having neuroprotective properties (whatever that means).

    There is a thread here on s4me regarding an ME study of DCA where the author, a doctor, engaged in the thread. Unfortunately there is no discussion on possible mitochondria effects, instead its "stress" so unfortunately nothing of interest of a biological discussion in the comments
    https://www.s4me.info/threads/treat...th-sodium-dichloroacetate-comhaire-2018.2885/

    Lets see if you find anything interesting........
     
    Annamaria, Trish, sb4 and 2 others like this.

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