1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 18th March 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Connection between lactate, hypoxia, and inflammation

Discussion in 'Other health news and research' started by Guest 2176, Dec 10, 2019.

  1. Guest 2176

    Guest 2176 Guest

  2. Guest 2176

    Guest 2176 Guest

    Hypoxia and glycolysis have long been appreciated to promote immune cell activation. In 2019, several studies highlighted a counterbalancing homeostatic function for the glycolytic metabolite lactate. Lactate directly suppresses signalling pathways and modifies histones to play an important role in regulating macrophage polarization, tumour immunity and antiviral responses.
     
    MeSci, Amw66, ScottTriGuy and 3 others like this.

Share This Page