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Collating Brain Research in ME

Discussion in 'BioMedical ME/CFS Research' started by Trish, Jan 26, 2019.

  1. Trish

    Trish Moderator Staff Member

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    The aim of this thread is to collect a list of brain imaging studies of ME patients, with links to threads on each study.

    We have in our library a thread by @Woolie that explains the different types of neuroimaging and what to look out for in assessing the quality of a study:
    Brain Studies of MECFS: A Primer

    This post will be used to add to the list as new research is published.

    To discuss the individual studies, go to its own thread. Please add any more to this thread and I will add them to this list.
    ........................

    PET
    Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study by Yasuhito Nakatomi et al,
    Paper here Thread here


    Brain Science on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2018, Watanabe.
    Abstract here Thread here

    ........................

    MRI
    Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome, 2016 by Barnden et al.
    Paper here


    Elevations of Ventricular Lactate Levels Occur in Both Chronic Fatigue Syndrome and Fibromyalgia, 2017, by Natelson et al.
    Paper here

    Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome, 2018, Barnden et al.
    Paper here Thread here


    Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome, 2018, van der Schaaf et al.
    Paper here Thread here

    Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome, 2014, Zeineh, Montoya et al
    Paper here Thread here


    ....................


    sMRI

    Structural brain changes versus self-report: machine-learning classification of CFS patients, 2018, Staud et al
    Paper here Thread here
    ....................

    fMRI

    Brain function characteristics of chronic fatigue syndrome: A task fMRI study, 2018, et al.
    Paper here Thread here

    Neural consequences of post-exertion malaise in Myalgic Encephalomyelitis /Chronic Fatigue Syndrome, 2017, Cook et al.
    Paper here Thread here


    ....................

    Proton MRS

    Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology, 2012, Shungu et al
    Paper here


    Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome, 2003, Chaudhury et al.
    Paper here


    Relative increase in choline in the occipital cortex in chronic fatigue syndrome, 2002, Puri et al.
    Paper here


    .........................

    MRS

    Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy, 2019, Younger et al.
    Paper here Thread here
    ......................

    SPECT

    Brainstem perfusion is impaired in chronic fatigue syndrome, 1995, by Costa et al.
    Paper here
    ...............................

    Other types of imaging

    Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging, 2018, Kimura et al.
    Paper here Thread here
    ...................

    Review papers

    Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods, 2019, Van Elzakker et al.
    Paper here Thread here

    ............................

    Other lists of brain studies in ME

    Reference list compiled in 2017 by Suzy Chapman and Mary Dimmock here

    ..........................





     
    Last edited: Jan 26, 2019
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  2. Trish

    Trish Moderator Staff Member

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    The idea for this thread came from a Twitter thread created by Dr Mark Guthridge who listed 10 brain studies and said a bit about each.

     
    Last edited: Jan 26, 2019
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  3. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

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  4. Trish

    Trish Moderator Staff Member

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  5. Peter Trewhitt

    Peter Trewhitt Senior Member (Voting Rights)

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    Thank you @Trish a very useful thread.

    I will follow up on the links when able to.

    I am particularly interested in working out what of our cognitive problems relate to generalised reversible neurological issues such as brain inflammation or reduced oxygen supply and what if any relate to focal irreversible neurological damage. What is transient, analogous to such as the effects of being tired or being drunk and what if anything is permenant, analogous to the effects of a CVA or such as Alzheimer's?

    For example in MS, during an acute episode, there is general 'inflammation' (?) which largely resolves, but can leave some less widespread permenant neurological damage (in this case demyelination).
     
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