Review Clinical Implications of COVID-19-Related Endothelial Dysfunction, 2024, Aljadah et al.

Discussion in 'Long Covid research' started by SNT Gatchaman, Jul 27, 2024.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Clinical Implications of COVID-19-Related Endothelial Dysfunction
    Aljadah; Khan; Beyer; Chen; Blanker; Widlansky

    Endothelial dysfunction represents a measurable and early manifestation of vascular disease. Emerging evidence suggests cardiovascular risk remains elevated after COVID-19 infection for at least 12 months, regardless of cardiovascular disease status prior to infection.

    We review the relationship between the severity of endothelial dysfunction and the severity of acute COVID-19 illness, the degree of impairment following recovery in both those with and without postacute sequalae SARS-CoV-2 infection, and current therapeutic efforts targeting endothelial function in patients following COVID-19 infection. We identify gaps in the literature to highlight specific areas where clinical research efforts hold promise for progress in understanding the connections between endothelial function, COVID-19, and clinical outcomes that will lead to beneficial therapeutics.

    Link | PDF (JACC: Advances)
     
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