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Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes, 2022, Victòria Ceperuelo-Mallafré et al

Discussion in 'Epidemics (including Covid-19, not Long Covid)' started by Mij, Sep 14, 2022.

  1. Mij

    Mij Senior Member (Voting Rights)

    Messages:
    8,204
    Background: Coronavirus-19 (COVID-19) disease is driven by an unchecked immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus which alters host mitochondrial-associated mechanisms. Compromised mitochondrial health results in abnormal reprogramming of glucose metabolism, which can disrupt extracellular signalling. We hypothesized that examining mitochondrial energy-related signalling metabolites implicated in host immune response to SARS-CoV-2 infection would provide potential biomarkers for predicting the risk of severe COVID-19 illness.

    Methods: We used a semi-targeted serum metabolomics approach in 273 patients with different severity grades of COVID-19 recruited at the acute phase of the infection to determine the relative abundance of tricarboxylic acid (Krebs) cycle-related metabolites with known extracellular signaling properties (pyruvate, lactate, succinate and α-ketoglutarate). Abundance levels of energy-related metabolites were evaluated in a validation cohort (n=398) using quantitative fluorimetric assays.

    Results: Increased levels of four energy-related metabolites (pyruvate, lactate, a-ketoglutarate and succinate) were found in critically ill COVID-19 patients using semi-targeted and targeted approaches (p<0.05). The combined strategy proposed herein enabled us to establish that circulating pyruvate levels (p<0.001) together with body mass index (p=0.025), C-reactive protein (p=0.039), D-Dimer (p<0.001) and creatinine (p=0.043) levels, are independent predictors of critical COVID-19. Furthermore, classification and regression tree (CART) analysis provided a cut-off value of pyruvate in serum (24.54 µM; p<0.001) as an early criterion to accurately classify patients with critical outcomes.

    Conclusion: Our findings support the link between COVID-19 pathogenesis and immunometabolic dysregulation, and show that fluorometric quantification of circulating pyruvate is a cost-effective clinical decision support tool to improve patient stratification and prognosis prediction.

    https://www.frontiersin.org/article...SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlv
     
    Last edited by a moderator: Sep 14, 2022
    SNT Gatchaman, Trish and RedFox like this.
  2. Mij

    Mij Senior Member (Voting Rights)

    Messages:
    8,204
    The levels of four energy-related metabolites decrease as the disease progresses.
     
    RedFox, alktipping and Amw66 like this.

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