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Brain 18F-FDG PET imaging in outpatients with post-COV-19 conditions: findings and associations with clinical characteristics, 2022, Goehringer et al

Discussion in 'Long Covid research' started by Cheshire, Nov 3, 2022.

  1. Cheshire

    Cheshire Moderator Staff Member

    Messages:
    4,675
    Abstract
    Background

    Brain 18F-FDG PET imaging has the potential to provide an objective assessment of brain involvement in post-COVID-19 conditions but previous studies of heterogeneous patient series yield inconsistent results. The current study aimed to investigate brain 18F-FDG PET findings in a homogeneous series of outpatients with post-COVID-19 conditions and to identify associations with clinical patient characteristics.

    Methods
    We retrospectively included 28 consecutive outpatients who presented with post-COVID-19 conditions between September 2020 and May 2022 and who satisfied the WHO definition, and had a brain 18F-FDG PET for suspected brain involvement but had not been hospitalized for COVID-19. A voxel-based group comparison with 28 age- and sex-matched healthy controls was performed (p-voxel at 0.005 uncorrected, p-cluster at 0.05 FWE corrected) and identified clusters were correlated with clinical characteristics.

    Results
    Outpatients with post-COVID-19 conditions exhibited diffuse hypometabolism predominantly involving right frontal and temporal lobes including the orbito-frontal cortex and internal temporal areas. Metabolism in these clusters was inversely correlated with the number of symptoms during the initial infection (r =  − 0.44, p = 0.02) and with the duration of symptoms (r =  − 0.39, p = 0.04). Asthenia and cardiovascular, digestive, and neurological disorders during the acute phase and asthenia and language disorders during the chronic phase (p ≤ 0.04) were associated with these hypometabolic clusters.

    Conclusion
    Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.

    https://link.springer.com/article/10.1007/s00259-022-06013-2
     
  2. CRG

    CRG Senior Member (Voting Rights)

    Messages:
    1,857
    Location:
    UK

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