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Bansal (eye) pupil reaction test

Discussion in 'Laboratory and genetic testing, medical imaging' started by Amw66, Mar 25, 2022.

  1. Amw66

    Amw66 Senior Member (Voting Rights)

    Last edited by a moderator: Mar 28, 2022
  2. JemPD

    JemPD Senior Member (Voting Rights)

    really? i wonder what that is?
    Tia, Sean, NelliePledge and 1 other person like this.
  3. Dolphin

    Dolphin Senior Member (Voting Rights)

    Investigating unexplained fatigue in general practice with a particular focus on CFS/ME
    Amolak S Bansal

  4. Dolphin

    Dolphin Senior Member (Voting Rights)


    Some information on an unpublished study on pupil responses:

    Dr Bansal mentions he has observed unusual responses by the pupils to light. I thought I would highlight a study that was done in the late 1990s looking at this. Unfortunately the researcher passed away before it could be published. Perhaps there are better sources than these lay articles but I thought they might be of some use in the hope that the finding might be followed up again.

  5. Woolie

    Woolie Senior Member

    Smells a bit off to me, this.

    Pupillometry is used a lot in cognitive psychology because pupils are markers of all sorts of things. People's pupils will repond to changes in the nature of some repeating stimulus, even if its auditory (e.g, beep, beep, beep, boop, beep), they'll respond to pretty much any attention-grabbing stimulus. They are also pretty sensitive markers of changes in affect, and to painful sensations anywhere in the body.

    So there are dozens of reasons why PwME might show unusual pupil responses, which have nothing to do with abnormalities in the brain stem.

    These responses might be tracking some of the cognitive limitations associated ME that change the way people orient to new stimuli, or they could be tracking some other feature, such as automonic abnormaities. You really can't say, its just an outcome measure, and the trick is in teasing apart what factors are causing he abnormalties.
  6. Sean

    Sean Senior Member (Voting Rights)

    Sounds like brain scans. Sure it is objective data, but what does it mean?
    Peter Trewhitt, Forbin and Woolie like this.
  7. Forbin

    Forbin Senior Member (Voting Rights)

    I think it would only be a "key" to chronic fatigue syndrome if it were very specific to ME/CFS patients as well as a common finding in ME/CFS patients.

    I've certainly experienced visual problems that I connect to ME - mainly related to difficulties with convergrance and "fusion" of the stereo image - but also with visual "flicker," which might be caused by rapid changes in pupil diameter, but I think there's also likely a strong link between the vestibular system and "aiming" difficulties with the eyes.

    The wide number of possible combinations of various visual and balance problems makes me sceptical that a single "signature" will cover a high percentage of patients, but I'm glad someone is actually studying this. It might at least lead to patients with these problems being further evaluated for possible ME/CFS
    Wonko, alktipping, Tia and 1 other person like this.
  8. Hutan

    Hutan Moderator Staff Member

  9. CRG

    CRG Senior Member (Voting Rights)

    Last edited: Apr 6, 2022

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