Auvelity (dextromethorphan HBr and bupropion HCl)

I would be curious to hear about experiences with this drug or separate generic combo. Approved in US in August 2022 for the treatment of major depressive disorder. Apparently the bupropion makes the DXM long lasting.

The Bateman Horne center in Utah prescribes dextromethorphan 15mg twice a day.

Jarred Younger has also looked at it
https://www.healthrising.org/blog/2021/03/02/dextromethorphan-fibromyalgia-neuroinflammation-study/

From wiki

"Dextromethorphan acts as an NMDA receptor antagonist, σ1 receptor agonist, and serotonin–norepinephrine reuptake inhibitor, among other actions, while bupropion acts as a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor negative allosteric modulator.[1][13] Bupropion is also a potent inhibitor of CYP2D6, and thereby inhibits the metabolism of dextromethorphan.[13] Dextromethorphan/bupropion has less activity as an NMDA receptor antagonist than dextromethorphan alone.[11] This is because bupropion is a potent CYP2D6 inhibitor and prevents the bioactivation of dextromethorphan into dextrorphan, a much more potent NMDA receptor antagonist and weaker serotonin reuptake inhibitor than dextromethorphan itself.[11] The mechanism of action of dextromethorphan/bupropion in the treatment of depression is unknown, although the preceding pharmacological actions are assumed to be involved.