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Anyone with psoriasis or psoriatic arthritis taking a biologic and its effect on ME

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by leokitten, Jan 16, 2018.

  1. leokitten

    leokitten New Member

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    Wondering if anyone here on S4ME who has psoriasis or psoriatic arthritis and taking a biologic? Which one? How has it affected your ME/CFS symptoms?
     
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  2. Hutan

    Hutan Moderator Staff Member

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    Milo, ladycatlover and leokitten like this.
  3. leokitten

    leokitten New Member

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    Thanks! I'm glad to see you too @Hutan and other great members from PR. I actually knew people were moving but didn’t know what the new site would be, I found it when doing a google search for info related to this thread.
     
    Last edited: Jan 19, 2018
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  4. ladycatlover

    ladycatlover Senior Member (Voting Rights)

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    Welcome to the forum @leokitten. :)

    I recently got diagnosis of psoriasis, but don't take anything for it. Just have petroleum based cream to use for washing in bath/shower. Can't say it's helping much, and it leaves the bath a mess! :rolleyes: I feel like ringing a bell "Unclean! unclean!" from the skin shedding in our bedroom. Yuck. :cry: I'm obviously not affected very badly by it, but it's irritating. Hopefully someone more knowledgeable will be along soon with more helpful response! :)

    Best wishes from Liverpool, where I'm really enjoying looking at the new moon out of my bedroom window. :)
     
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  5. ahimsa

    ahimsa Senior Member (Voting Rights)

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    My brother has psoriatic arthritis but he does not have ME. But if you'd like me to ask him about what treatments he is taking then I can do that.
     
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  6. Allele

    Allele Senior Member (Voting Rights)

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    Great to see you here, @leokitten. I don't have psoriasis but wanted to say hello!
     
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  7. leokitten

    leokitten New Member

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    Thanks for the offer @ahimsa, I am familiar with the treatments that are available, I’ll explain more the reason for my thread question...

    I’ve had a rarer form psoriasis since my late teens. It was constantly misdiagnosed by doctors for so many years and therefore not treated properly. In my mid 30s before getting ME it started getting worse and then after getting ME it got a lot worse and harder to control.

    It’s definitely within the realm of possibility that my living with psoriasis untreated for so long caused immune system changes that put me at higher risk of getting ME (since it really is a systemic auto-inflammatory disease, we only see the skin part of it)

    I believe there is a definite connection between the two diseases, for me in particular the symptoms of both ME and psoriasis go up and down fairly well together (the “flare ups”). Maybe the connection is as superficial as both just being immune-mediated, though could be more.

    Having ME has made me much more cautious about taking a biologic for my psoriasis. For a couple years now, I’ve been at the point where it cannot be controlled with topicals and is debilitating on its own. My dermatologist has been telling me for a long time that we should think about a biologic. I’ve also been waiting for newer, more targeted biologic classes to come out since they would potentially have a better safety profile and fewer side effects.

    In the last two years, IL-17 and IL-23 targeting biologics have been approved. They are much more targeted, efficacious, and potentially safer than TNF-a targeting biologics. Even so, suppressing IL-17 or IL-23 carries some small risk of viral reactivation and other infections.

    Since we still know next to nothing about the pathology of ME I'm cautious about taking a biologic that will suppress a part of my immune system and potentially make the ME worse.

    If the theory that ME is perpetuated by smoldering infections or an deficient immune system that cannot adequately control ubiquitous viruses then taking such a biologic is of course a bad idea. Though if the theory that ME is perpetuated by an auto-inflammatory and dysfunctional immune system where any possible trigger is long gone then taking an IL-17 or IL-23 targeting biologic for one’s psoriasis could be beneficial.

    I welcome any thoughts.
     
    Last edited: Jan 22, 2018
  8. ahimsa

    ahimsa Senior Member (Voting Rights)

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    Thanks for the explanation, @leokitten

    I wish I could help with some brainstorming but this kind of medical discussion is completely out of my league.
     
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