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Acute and persistent symptoms in children with PCR-confirmed SARS-CoV-2 infection compared to test-negative children in England.., 2021, Zavala et al

Discussion in 'Long Covid research' started by Andy, Dec 2, 2021.

  1. Andy

    Andy Committee Member

    Hampshire, UK
    Full title: Acute and persistent symptoms in children with PCR-confirmed SARS-CoV-2 infection compared to test-negative children in England: active, prospective, national surveillance


    Most children recover quickly after COVID-19, but some may have on-going symptoms. Follow-up studies have been limited by small sample sizes and lack of appropriate controls

    We used national testing data to identify children aged 2-16 years with a SARS-CoV-2 PCR test during 01-07 January 2021 and randomly selected1,500 PCR-positive cases and 1,500 matched PCR-negative controls. Parents were asked to complete a questionnaire about the acute illness and pre-specified neurological, dermatological, sensory, respiratory, cardiovascular, gastrointestinal, mental health (including emotional and behavioural well-being) and other symptoms experienced at least five times at one month after the PCR test.

    Overall, 35.0% (859/2456) completed the questionnaire, including 38.0% (472/1242) cases and 32% (387/1214) controls. of whom 68% (320/472) and 40% (154/387) were symptomatic, respectively. The most prevalent acute symptoms were cough (249 /859, 29.0%), fever (236/859, 27.5%), headache (236/859, 27.4%) and fatigue (231/859, 26.9%). One month later, 21/320 (6.7%) of symptomatic cases and 6/154 (4.2%) of symptomatic controls (p=0.24) experienced on-going symptoms. Of the 65 on-going symptoms solicited, three clusters were significantly (p<0.05) more common, albeit at low prevalence, among symptomatic cases (3-7%) than symptomatic controls (0-3: neurological, sensory and emotional and behavioural wellbeing. Mental health symptoms were reported by all groups but more frequently among symptomatic cases than symptomatic controls or asymptomatic children.

    Children with symptomatic COVID-19 had a slightly higher prevalence of on-going symptoms than symptomatic controls, and not as high as previously reported. Healthcare resources should be prioritised to support the mental health of children.

    Open access, https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab991/6446232
    Simon M and Peter Trewhitt like this.

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