Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis, 2020, Bai et al

https://jnnp.bmj.com/content/91/1/21.abstract

Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials

Hard to say whether this is GIGO without an in-depth look but this was to be expected considering growing evidence that depression may have little to do with psychology and much more to do with the immune system. Belief in magical psychology is likely to remain steadfast in the next few years but it will essentially face a complete breakdown of all their sacred cows.

Considering the horrible, and largely denied, side-effects of antidepressants, this could be huge. Psychiatry has a huge reckoning coming their way over this, continuing to deny the side-effects, especially of withdrawal, and patient reports as essentially meaningless.

Posted without comment but Keith Laws follows this general topic closely:
https://twitter.com/user/status/1212795021805666305

 

Sci-hub link

If this link doesn't work in your country, try to insert the doi-number (in this case: 10.1136/jnnp-2019-320912) here.

 

Are those high or low effect sizes? I can't remember how those statistics work

And can somebody remind me what confidence intervals mean? I understand p-values much more easily, don't like it when papers use confidence intervals instead.

And what does I2 mean??