Energy metabolism in ME/CFS

Main studies

Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome.
Smits B, van den Heuvel L, Knoop H, Küsters B, Janssen A, Borm G, et al.
Mitochondrion.
2011
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Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients.
Armstrong CW, McGregor NR, Lewis DP, Butt HL, Gooley PR.
Metabolomics
2015
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Abnormalities of AMPK activation and glucose uptake in cultured skeletal muscle cells from individuals with chronic fatigue syndrome.
Brown AE, Jones DE, Walker M, Newton JL.
PLoS ONE.
2015
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Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome.
Billing-Ross P, Germain A, Ye K, Keinan A, Gu Z, Hanson MR.
Journal of Translational Medicine.
2016
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Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome.
Fluge OM O.; Bruland O.; Risa K.; Dyrstad S.E.; Alme K.; Rekeland I.G. et al.
JCI Insight.
2016
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Elevated Energy Production in Chronic Fatigue Syndrome Patients.
Lawson NH, CH.; March D.; Wang X.
Journal of Nature and Science.
2016
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Metabolic features of chronic fatigue syndrome.
Naviaux RN J.; Li K.; Bright A.T.; Alaynick W.A.; Wang L.; Baxter A. et al.
PNAS.
2016
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Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism†.
Germain AR, D.; Levine S.M.; Hanson M.R.
Molecular Biosystems.
2017
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Cellular bioenergetics is impaired in patients with chronic fatigue syndrome
Cara Tomas , Audrey Brown, Victoria Strassheim, Joanna Elson, Julia Newton, Philip Manning
PlosOne
2017
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Link to S4ME thread