1. Sign our petition calling on Cochrane to withdraw their review of Exercise Therapy for CFS here.
    Dismiss Notice
  2. Guest, the 'News in Brief' for the week beginning 18th March 2024 is here.
    Dismiss Notice
  3. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Phase III Rituximab Trial - News

Discussion in 'ME/CFS research news' started by Scarecrow, Nov 21, 2017.

Tags:
  1. Awol

    Awol Senior Member (Voting Rights)

    Messages:
    219
  2. Sasha

    Sasha Senior Member (Voting Rights)

    Messages:
    3,769
    Location:
    UK
    That's 2,200 words, which is a big read for a lot of PWME. The gist seems to be that in the light of the null results from the Norwegian rtx trial, IiME won't be doing a rtx trial and has about £350,000 remaining in its rtx pot, after having spent some of it on B-cell work at UCL. That pot will now be spent on other biomedical research, as yet unspecified. But, given that some of that appears to have been pledges for the rtx trial, it's not clear to me how much of that £350,000 pot is actual cash and whether any pledges might now be withdrawn.

    The relevant bit is right at the bottom:

     
  3. cyclamen

    cyclamen Established Member (Voting Rights)

    Messages:
    63
    Hi, I heard a rumor, that the Rituximab trial failed only because they run out of money. So they had to cut the planned doses in half and this is responsible for the 0 effect if compared to the placebo group.
    Is there any sound base to this?

    I apologize, if this topic was already covered.
     
    Inara likes this.
  4. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

    Messages:
    2,731
    Where did you hear that? It sounds unlikely. Trials don't usually 'run out of money', because you ask for however much you need to do the trial upfront.
     
  5. cyclamen

    cyclamen Established Member (Voting Rights)

    Messages:
    63
    Thank you for answering.
    A rumor between people with ME in a Facebook group. Haven’t you heard it before?

    I thought so too, but before stepping in I want to be sure.
     
    Inara and Skycloud like this.
  6. Daisybell

    Daisybell Senior Member (Voting Rights)

    Messages:
    2,628
    Location:
    New Zealand
    I think this so unlikely that you can safely dismiss this rumor as rubbish.....
     
    inox, MeSci, Solstice and 9 others like this.
  7. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    Messages:
    13,274
    Location:
    London, UK
    This was not the case.
     
    merylg, Lidia, Cheshire and 11 others like this.
  8. Liv aka Mrs Sowester

    Liv aka Mrs Sowester Senior Member (Voting Rights)

    Messages:
    1,201
    Trials secure funding before starting. If they had run out of money they would have applied or appealed for more.
    It sounds very like some people are trying to avoid having to let go of hope, which is understandable but we really need to accept that the trial team have been honest and displayed consistent integrity.
     
  9. Alvin

    Alvin Senior Member (Voting Rights)

    Messages:
    3,309
    This does not pass the laugh test. And rumours/gossip are about as reliable as a pyramid scheme
     
  10. Dial It In

    Dial It In Established Member (Voting Rights)

    Messages:
    34
    Location:
    Australia
    Some are doing very well out of crypto........
     
  11. Alvin

    Alvin Senior Member (Voting Rights)

    Messages:
    3,309
    I do not understand?
     
    NelliePledge likes this.
  12. Denise

    Denise Senior Member (Voting Rights)

    Messages:
    470
    IF there were any basis to this rumor the researchers would have violated many ethical and scientific norms, as well as having questionable financial planning. In such a (theoretical) case we would do well to steer clear of those involved. However, these researchers have been forthcoming about the results of their study and that is laudable.
    We all want results that benefit patients. The study results indicate that Rituxan isn't effective for most patients. While that may be difficult to accept, it is worth keeping in mind that having honest and thorough researchers on our side is to our benefit (in the long run).
     
    TigerLilea, deleder2k, Hutan and 14 others like this.
  13. Alvin

    Alvin Senior Member (Voting Rights)

    Messages:
    3,309
    I suspect rumours like these are started to "allay" disappointment and latch on to false hope.
     
    Last edited: Aug 11, 2018
  14. Diluted-biscuit

    Diluted-biscuit Senior Member (Voting Rights)

    Messages:
    518
    We still learn things from failed trials too. Well done research pushes us forward whatever the result.
     
  15. Inara

    Inara Senior Member (Voting Rights)

    Messages:
    2,734
    How did the discussion go?
     
  16. Little Bluestem

    Little Bluestem Senior Member (Voting Rights)

    Messages:
    1,450
    I recall reading that Thomas Edison once said that he knew {some large number} ways not to make a light bulb. :emoji_bulb:
     
  17. Forbin

    Forbin Senior Member (Voting Rights)

    Messages:
    1,581
    Location:
    USA
    There are a lot of variations on this, including, "I have not failed. I have just found 10,000 ways that won't work." It's unclear if he actually said this, though.

    During Edison's life, however, a colleague quoted him as responding to a question about a lack of results with,"‘Results!' Why, man, I have gotten a lot of results! I know several thousand things that won’t work."

    It's a sentiment about persistence that he expressed in a variety of ways, such as, "Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time."
     
  18. Milo

    Milo Senior Member (Voting Rights)

    Messages:
    2,107
    any updates from our Norwegian members about when the study will be published, and then the Cyclophosphamide one would be due too? Thanks. (I know, I assume that because you are norwegian, you should be able to know... :laugh: )
     
    adambeyoncelowe likes this.
  19. Kalliope

    Kalliope Senior Member (Voting Rights)

    Messages:
    6,238
    Location:
    Norway
    Øystein Fluge will have a lecture at the upcoming ME-symposium at Stanford - this can be streamed live.
    People from his research team will also have lectures at two ME conferences in Sweden in October, also this will be available for streaming (but the lectures will probably be in Norwegian).

    I hope we'll learn more about RituxME and CycloME then :)
     
    Woolie, Snowdrop, Lisa108 and 12 others like this.
  20. Kalliope

    Kalliope Senior Member (Voting Rights)

    Messages:
    6,238
    Location:
    Norway
    The research team has just received more funds to continue their work.
    More about that here: https://www.s4me.info/threads/news-from-scandinavia.647/page-16#post-104057

    In a news article from the foundation who has given the funds, it says that detailed results from RituxME and CycloME are expected to be published in international journals during this autumn.

    https://kavlifondet.no/en/2018/09/press-release-the-kavli-trust-renews-its-support-for-me-research-at-haukeland-university-hospital/

    E
    dit to add: Seems the English version of the article is a bit shorter than the original version and that the information about the publications of RituxME and CycloME are only in the Norwegian one.
     
    Last edited: Sep 14, 2018

Share This Page