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Ongoing ME/CFS studies

Discussion in 'Science Library (Read only)' started by Cheshire, Nov 26, 2017.

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  1. Cheshire

    Cheshire Senior Member (Voting Rights)

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    Multidimensional studies


    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome at the National Institutes of Health
    Lead researcher: Avindra Nath
    National Institute of Neurological Disorders and Stroke (NINDS)
    Study Start Date: January 21, 2016
    Estimated Study Completion Date: September 15, 2020
    More information
    Dr Avindra Nath presenting the study (video)


    ME/CFS Severely ill Big Data Study
    Open Medicine Foundation
    More information



    NIH ME/CFS centers:
    (S4ME thread)

    *Cornell ME/CFS Collaborative Research Center

    Lead researcher: Maureen Hanson, Ph.D.
    Cornell University, Ithaca, New York
    Center registration
    More information

    Main research projects:
    - Brain imaging study, led by Dikoma Shungu (See the neurology studies list below for more information)
    - Extracellular vesicles, led by Hanson (See the immunology studies list below for more information)
    - RNAs in white blood cells, led by Andrew Grimson (See the genetic studies list below for more information)

    * Center for Solutions for ME/CFS
    Lead researcher: W. Ian Lipkin, M.D.
    Columbia University, New York City
    Center registration
    More Information

    *Topological Mapping of Immune, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms
    Lead researcher: Derya Unutmaz, M.D.
    The Jackson Laboratory, Farmington, Connecticut
    Center registration
    More Information

    *Data Management and Coordinating Center (DMCC) for the ME/CFS Collaborative Research Centers
    Lead researcher: Rick L. Williams, Ph.D.
    Research Triangle Institute, Research Triangle, North Carolina
    Center registration


    ME/CFS Collaborative Research Center at Stanford

    Lead researcher: Ronald W. Davis
    Research projects:
    T cells and the molecular immunology of ME/CFS
    Extended big data study in families
    Developing blood-based diagnostic and drug screening technology
    More information
    S4ME thread

    Immunology


    Immune System Dysfunction
    Lead researchers: Professor Stephen Todryk and Professor Julia Newton
    ME Association Ramsay Research Fund / Action for ME
    Start: 2014
    More information

    Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS) (CycloME) Treatment study
    Lead researchers: Mella Olav, Øystein Fluge
    Haukeland University Hospital
    Start: 2015
    Estimated Study Completion Date: January 2017
    More information

    The role of autoantibodies in ME/CFS
    Lead researchers: Dr Madlen Löbel & Prof. Carmen Scheibenbogen
    Institute of Medical Immunology, Charité University Medicine Berlin, Berlin, Germany
    MERUK
    More Information

    An immunosignature assay for rituximab therapy?
    Lead researcher: Prof. David Patrick
    School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, USA
    MERUK
    More information

    Lymphocyte phenotype and cytokine production in ME/CFS patients and patients treated with chemotherapy for breast cancer
    Lead researchers: Dr Clive Carter, Dr Philip Wood and colleagues
    Leeds NHS Teaching Hospital NHS Trust, St James’s University Hospital, Leeds
    MERUK
    More information

    Ampligen in Chronic Fatigue Syndrome Treatment study
    Hemispherx
    Study Start Date: March 1997
    Estimated Study Completion Date: February 2019
    More information
    S4ME thread


    Extracellular vesicles
    Lead researcher: Maureen Hanson
    Cornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center
    More Information

    Combatting oxidative stress
    Lead researchers: Dr Faisel Khan, Prof JD Hayes, Prof J Belch, et al.
    Vascular & Inflammatory Diseases Research Unit, Division of Cardiovascular & Diabetes Medicine and Division of Cancer Research, Ninewells Hospital & Medical School, Dundee, UK
    MERUK
    More information

    Immunoadsorption in patients with autoantibodies to ß adrenergic receptors Treatment study
    Lead researcher: Carmen Scheibenbogen
    Charité, Berlin, Germany
    Fresenius Medical Care
    More information (German)

    HyQvia in patients with immunoglobulin deficiency, frequent infections and CFS Treatment study
    Charité, Berlin, Germany
    Baxalta
    More information (German)
    Information on HyQvia

    Chronic fatigue syndrome: Leptin, interleukin 6 and clinical symptoms
    Lead researcher: Michael Musker
    South Australian Health And Medical Research Institute (SAHMRI), Australia
    More information

    Immuno-senescence and cell-cycle analysis in the pathophysiology of ME/CFS
    Lead researchers: Dr. Sheila Stewart, Dr. Masashi Narita
    Washington University (USA), Cambridge University (UK)
    SMCI
    More information

    Biomarkers for initiation (infection) and metabolic derangement in ME/CFS
    Lead researchers: Drs. Blomberg, Bergquist, Gottfries, and Zachrisson
    Gottfries clinic, Mölndal, Uppsala University Hospital (Sweden)
    SMCI, Ramsay Award Program (2017)
    Start: 2018

    More information

    Immunometabolism of T cells and monocytes in ME/CFS
    Lead researchers: Drs. Carmen Scheibenbogen and Franziska Sotzny
    Charité – Universitätsmedizin Berlin (Germany)
    SMCI, Ramsay Award Program (2017)
    Start: 2018

    More information

    Metabolic Analysis of B Cell Maturation
    Lead researchers: Chris Armstrong, Fane Mensah and Professor Jo Cambridge
    Melbourne Bioanalytics (Australia), University College London (UK)
    SMCI, Ramsay Award Program (2016)
    More information
    SMCI presentation


    Metabolic Assessment of Natural Killer Cells
    Lead researchers: Drs. Isabel Barao-Silvestre, Ruben Dagda, and Victor Darley-Usmar
    University of Nevada Reno, University of Alabama, Birmingham (USA)
    SMCI, Ramsay Award Program (2016)
    More information

    Identifying Autoimmune signatures in ME/CFS
    Lead researchers: Dr. Carmen Scheibenbogen and Madlen Lobel
    Charité University Medicine Berlin, Charité Universitatsmedizin Berlin (Germany)
    SMCI, Ramsay Award Program (2016)
    More information

    The potential role of HHV-6 in ME/CFS
    Lead researcher: Bhupesh Prusty
    Julius Maximilian University of Wurzburg (Germany)
    SMCI, Ramsay Award Program (2016)
    More information

    Investigation of human endogenous retrovirus expression in individuals with myalgic encephalomyelitis
    Lead researcher: Dr Camila Malto Romano
    USP - Universidade de São Paulo (Brazil)
    Using UK ME CFS Biobank
    More information

    Droplet digital PCR for evaluation of associations between human Herpes virus infection and Myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS)
    Lead researchers: Eleanor Riley, Jackie Cliff
    London Sch/Hygiene & Tropical Medicine
    More information

    A longitudinal immunological and virological study for ME CFS biomarker discovery
    Lead researcher: Luis Nacul
    London Sch/Hygiene & Tropical Medicine
    More information

    Energy metabolism

    Examining Mitochondria in ME/CFS
    Lead researcher: Dr Karl Morten
    ME Association Ramsay Research Fund
    Using UK Biobank samples
    Start: 2017
    More information
    S4ME thread


    Comparison of results from a commercial and NHS blood test to assess mitochondrial function
    Lead researcher: Dr Sarah Jayne Boulton
    ME Association Ramsay Research Fund
    More information

    Abnormalities in Mitochondrial Function in Skeletal Muscle
    Lead researcher: Professor Anne McArdle
    ME Association Ramsay Research Fund/Medical Research Council
    Preliminary results (2015)
    More information


    Bioenergetics capacity, ATP production and potential drug targets using advanced technologies
    Lead researcher: Dr. Ralph Garippa
    Memorial Sloan Kettering Cancer Center (MSKCC), New York City (USA)
    SMCI
    More information

    Projects

    Longitudinal metabolic and genomic study
    Lead researcher: Chris Armstrong
    Melbourne Bioanalytics, Australia
    More information

    Mitochondrial Respiratory Function and Cellular Metabolism in Lymphoblasts
    Lead researcher: Chris Armstrong, Daniel Missailidis and Paul Fisher
    Melbourne Bioanalytics, LaTrobe University, Australia

    More information

    Muscles studies

    Investigating abnormalities in AMPK activation
    Lead researcher: Dr Audrey Brown
    Institute of Cellular Medicine, Newcastle University, Newcastle, UK
    MERUK
    More information

    Muscle metabolites in patients before and after exercise
    Lead researchers: Pr. Kevin Conley, Pr. David Maughan
    University of Washington
    SMCI, Cathleen J. Gleeson PhD Fund
    More information

    Neurology studies

    Neurological biomarkers in paediatric ME/CFS
    Lead researcher: Dr Sarah Knight and colleagues
    Murdoch Children’s Research Institute, The Royal Children’s Hospital, University of Melbourne, Melbourne, Australia
    MERUK
    More information

    Markers of neuroinflammation and oxidative stress
    Lead researcher: Dikoma Shungu
    Cornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center
    More information

    Interrogating the brain: experiments with laser-evoked potentials and cerebral blood flow
    Lead researchers: Prof. J. Nijs, Prof P. Cras, Prof F. visser, M. de Kooning and colleagues
    Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium
    MERUK
    More information

    Development of surrogate end-point biomarkers for chronic fatigue and myalgic encephalmyelitis/chronic fatigue syndrome (ME/CFS)
    Lead researcher: Watanabe
    Pet Scan study
    Japan
    More Information
    S4ME thread


    Exploring Brain Inflammation
    Lead researcher: Dr. Jarred Younger
    University of Alabama, Birmingham (USA)
    SMCI, Ramsay Award Program (2016)
    More information

    Projects

    Glial activation in brainstem

    Dr. Michael VanElzakker
    Massachusetts General Hospital
    More information
    S4ME thread



    Autonomic system

    ME/CFS: Activity Patterns and Autonomic Dysfunction
    Lead researcher: Fred Friedberg
    Stony Brook University New York, United States
    NIH funds
    Study Start Date: June 2016
    Estimated Study Completion Date: May 2020
    More information
    S4ME Thread




    If you have questions or want to make a suggestion, please go to the Librairy Discussions thread.
     
    Last edited: Dec 7, 2017
  2. Cheshire

    Cheshire Senior Member (Voting Rights)

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    Exercise studies

    Cardiopulmonary Exercise Testing as a Diagnostic Tool and a Quantitative Measure of Post-exertional Malaise in Myalgic Encephalopathy/Chronic Fatigue Syndrome

    Lead researcher: Per Ole Iversen
    University of Oslo
    Study Start Date: June 2014
    Estimated Study Completion Date: December 2018
    More information


    Effect of Exercise on Cognitive and Immune System Function

    Lead researchers: Dr Amolak Bansal and Dr Megan Arroll
    ME Association Ramsay Research Fund
    More information


    Host gene expression during post-exertional symptom flare in ME/CFS: a hypothesis generating study

    Lead researcher: Dr David Patrick
    School of Population and Public Health, University of British Columbia, British Columbia, Canada
    MERUK
    More information


    Connection between small fiber polyneuropathy and exertional intolerance during the course of cardiopulmonary testing

    Lead researcher: Dr. David M. Systrom
    Brigham and Women’s Hospital (BWH), Boston (USA)
    SMCI
    More information
    Cort Johnson's article on the study



    Genetic studies

    ME/CFS Genes Study

    Nova University
    More information
    S4ME thread


    Examination of MicroRNA profiles in PBMCs and exosome-enriched vesicles

    Lead researcher: Professor Elisa Oltra
    Catholic University of Valencia (Spain)
    ME Association Ramsay Research Fund
    Using UK Biobank samples
    Start: 2017 (estimated time to complete: 18 months)
    More information


    Metabolomics and Genetics Study

    Lead researchers: Robert Naviaux Ron Davis
    Open Medicine Fundation
    More information


    Two dimensional sequencing and machine learning to maximise genetic marker detection

    Lead researcher: Prof Brett Lidbury and colleagues
    The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    MERUK
    More information


    Epigenetics of the BDNF gene and its relevance for pain: an exploratory study

    Lead researchers: Prof Jo Nijs & Prof Lode Godderis
    Vrije Universiteit Brussel, University Hospital Brussels & University of Leuven
    MERUK
    More information


    RNAs in white blood cells

    Lead researcher: Andrew Grimson
    Cornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center
    More Information


    Effect of ME/CFS on epigenetic regulation in specific immune cell types

    Lead researchers: Drs. Lubov Nathanson, Vladimir Beljanski, Malav Suchin Trivedi, Elisa Oltra
    Nova Southeastern University (USA), Universidad Católica de Valencia (Spain)
    SMCI, Ramsay Award Program (2017)
    Start: 2018
    More information



    Microbiome

    Fecal microbiota transplant in chronic fatigue syndrome - an RCT Treatment study

    Funding: Norway Research Council
    University Hospital Northern Norway, Harstad"
    More Information
    FB trial Page (Norwegian)


    Comparing ME/CFS and IBS: gut immune and microbiome changes

    Lead researcher: Prof. Yan Yiannakou
    Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK
    MERUK
    More information

    S4ME thread

    Gut microbes in health and disease

    Lead researcher: Prof. Simon Carding
    Carding group
    More information


    Research into bioenergetics, metabolomics, and lipidomics

    Lead researchers: Dr. Hanson, Dr. Levine
    Cornell University, Metabolon
    SMCI
    More information


    Investigating alterations in the intestinal virome in CFS/ME

    Lead researchers: Ms. Fiona Newberry and Drs. Simon Carding & Tom Wileman
    Quadram Institute Bioscience, University of East Anglia (USA)
    SMCI, Ramsay Award Program (2017)
    Start: 2018
    More information


    Deciphering antibody reactivities against autoantigens & the microbiome in ME/CFS

    Lead researchers: Dr. Segal
    Weizmann Institute of Science
    SMCI, Ramsay Award Program (2017)
    Start: 2018
    More information



    Sleep

    Sleep Disturbance and Management

    Lead researchers: Professor Jason Ellis and Professor Julia Newton
    ME Association Ramsay Research Fund
    More information



    Cognition

    Difficulties with reading: an experimental study

    Lead researchers: Dr Claire Hutchinson, Dr Kevin Paterson and Dr John Maltby
    Vision and Language Research Group, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK
    MERUK
    More information



    Epidemiology

    Severely affected ME/CFS patients – a geographically defined study

    Lead researcher: Prof. Newton
    Newcastle University
    MERUK
    More information



    Diagnosis

    Evaluating the DePaul Symptom Questionnaire in the ME Research UK cohort: extension study

    Lead researcher: Prof. Julia Newton
    Institute for Ageing and Health, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    MERUK
    More information




    If you have questions or want to make a suggestion, please go to the Librairy Discussions thread.
     

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