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Is this the mechanism underlying PEM?

Discussion in 'Post-Exertional Malaise, Fatigue, and Crashes' started by Woolie, Dec 2, 2017.

  1. Rosie

    Rosie Established Member (Voting Rights)

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    How does one describe PEM in the severe years? Layers and layers of PEM is only way I can describe it. I couldn't bear to experience those full-on years again.
    MeSci, Barry, Skycloud and 6 others like this.
  2. lansbergen

    lansbergen Established Member (Voting Rights)

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    Yes, to me it feels like an immune response. Always did.
    Woolie, Rosie and Art Vandelay like this.
  3. Subtropical Island

    Subtropical Island Established Member (Voting Rights)

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    I'm very interested in this auto inflammatory lead. Please continue.
    (On a purely personal note: I'd especially like to know about any blood tests that might remain at variance from the norm even when not in the middle of a crash. Would be a dream to have something that easy to check.)
    Rosie likes this.
  4. Woolie

    Woolie Senior Member (Voting Rights)

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    @Subtropical Island, did you see this thread on autoinflammatory diseases?


    They're not the same as ME, but there may be similar mechanisms involved in both, at least in a subset of ME patients.
    Its really hard to know that for sure, because studies are all over the place, with no single cytokine standing out as abnormal in PwMEs. One recent review identified transforming growth factor beta (TGF-B) as reliably higher in PwMEs than in controls:


    I'm not a "typical" ME patient, but for me, the only permanently raised marker is my platelet counts, which are through the roof even when I feel okay.

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