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Cyclophosphamide drug questions?

Discussion in 'BioMedical ME/CFS News' started by Cornwall13, Nov 24, 2017.

  1. Cornwall13

    Cornwall13 Established Member

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    Wonder if someone could help clarify things please.

    Is the CycloME Part A trial being published any time soon?

    Does the results from rituximab lower expectations for the results for cyclo?

    Also, what is the theory behind cyclo working in ME?

    Thanks
     
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  2. BurnA

    BurnA Senior Member (Voting Rights)

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    It is due to be published early 2018.

    I can't speak about the expectations, but clearly the trial investigators believe it has an effect as they extended the original follow up period and then they proceeded with part B.

    I spoke with one of the investigators at iime and she indicated that it works, however I don't know if this means a whole lot, given they probably believed rituximab worked too.
     
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  3. Cornwall13

    Cornwall13 Established Member

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    Thanks for reply

    I'm just concerned that Cyclophosphamide treatment rationale is the same as rituximab. Due to the negative results from rituximab, whether this means cyclophosphamide probability of working is lowered
     
  4. Sasha

    Sasha Senior Member (Voting Rights)

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    It seems to have a completely different mechanism:

    https://www.medicinenet.com/cyclophosphamide/article.htm
     
  5. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

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    So would we be looking for what is considered a side effect for cancer patients?

    It is also something that suppresses B cells, which was my assumption about why they picked it. This possibly is bad news. Though there was something reassuring about cyclo looking more promising in with the :( news IIRC
     
  6. BurnA

    BurnA Senior Member (Voting Rights)

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    I think the background is similar, in that cancer patients with ME seemed to recover.
    However it does have a much broader effect than rtx, so if the problem is in the immune system, just because rtx failed, wouldn't necessarily suggest that cyclo will fail too.
     
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